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Abstract
The objective of this work was to study mercury chloride effects on the function and integrity of sea bass ( Dicentrarchus labrax) head kidney macrophages (S-HKM), and to evaluate the response of HgCl 2-exposed cells to macrophage activating factor(s) (MAF) produced by sea bass head kidney leukocytes. There was considerable variability in the effects of HgCl 2 on the production of reactive oxygen species (ROS) by S-HKM. When incubated with HgCl 2, cells from five out of nine fish tested showed a decrease in ROS production as compared to cells incubated with medium alone. In those cultures, MAF addition prevented the mercury chloride-induced decrease in ROS production. In other S-HKM cultures isolated from different fish, mercury chloride abrogated the up-regulating effect of MAF on the respiratory burst. MAF activation of the phagocytic activity of S-HKM was also impaired by HgCl 2 addition. Mercury chloride induced apoptosis in S-HKM cultures and MAF addition prevented this effect.
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