Abstract
Abstract Mercaptans have been measured in the breath for the first time. The only sulfur compounds detected in the breath of cirrhotic patients in hepatic coma or cirrhotic patients fed methionine were methanethiol, ethanethiol, and dimethyl sulfide. Normally, methanethiol is 6 to 20 per cent of the mercaptans excreted. Under fasting conditions in the absence of gastrointestinal bleeding, methane- and ethanethiol are approximately twice normal in severe decompensated cirrhosis. In the presence of gastro-intestinal bleeding, methanethiol increases further severalfold. After ingestion of methionine, the mercaptans are approximately doubled in the breath of normal persons but not in cirrhotic patients. The pungent odor of dimethyl sulfide appears in the breath of the cirrhotic patients, and the intensity of the odor is directly related to the amount of dimethyl sulfide in the breath.
Published Version
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