Abstract
Eutectic system is a mixture or solution which the ingredients solidify or liquefy simultaneously. A eutectic mixture is therefore that unique composition of two (or more) components that has the lower crystallization temperature or melting point. This aim of this study was to prepare and characterize the eutectic systems containing menthol, borneol, camphor and N-Ethyl-5-methyl-2-(1-methylethyl) cyclohexanecarboxamide (WS-3). Menthol is able to form liquid eutectic at room temperature with camphor in the ratio of 8:2, 7:3, 6:4 and 5:5 whereas menthol and borneol in the ratio of 8:2 and 7:3, menthol and WS-3 in the ratio of 6:4 and 1:1. The rheology behavior of all liquid eutectic systems was Newtonian flow which the surface tension was in the range of 28-29 mN/m. From contact angle measurement, all liquid eutectic systems were categorized as high wettability to the glass plate. The suitable liquid eutectic system for further application as liquid carrier for injectable active compounds was 1:1 menthol:camphor because of its lowest viscosity. IR spectra indicated that there was no chemical interaction of these two materials in the selected liquid eutectic mixture.
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