Abstract
changes in the ovary (including the presence of multi-oocyte follicles) that were associated with a 35% incidence of uterine tumors in animals at 18 months of age. “These animals had premature reproductive senescence,” said Newbold. “Their ovaries were malformed and not completely functional.” According to one report, the daily exposure of human infants to isoflavones in soy-based infant formulas is 6 to 11 times higher (based on body weight) than the dose that produces hormonal effects in adults consuming soy foods (Setchell et al. Lancet. 1997; 350:23-27). But for now, said Newbold, researchers don’t know how animal findings about genistein translate to the human population. “I think we have to be cautious,” she added. “Humans are exposed to a number of estrogenic or endocrine-disrupting compounds and it makes sense to decrease those exposures as much as possible.”
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