Menstrual regularity among early menarche girls and girls treated with GnRHa

Abstract

Objective To assess the effect of early menarche and treatment with gonadotropin-releasing hormone analogs(GnRHa)in girls with central precocious puberty(CPP)or early and fast puberty(EFP)on menstrual regularity. Methods Six hundred and ten healthy girls were recruited and their menarche age and menstrual cycle were recorded. 169 CPP or EFP girls treated with GnRHa were followed up, and their menarche age and menstrual cycle were also recorded. Results There were 129 girls with irregular menstruation among 610 healthy girls(21.1%), with 10 in 44 early menarche girls(22.7%)and 11 in 44 late menarche girls(25.0%). Compared with normal menarche girls(17.2%), no significant difference was found in the incidences of irregular menstruation in early and late menarche girls. The incidences of dysmenorrhea were 41.1% in normal girls and 50.0% in early menarche girls, without significant difference. There was a higher incidence of irregular menstruation in 113 CPP girls and 56 EFP girls treated with GnRHa compared with healthy girls(31.4% vs 21.1%, P 0.05). Fifty-seven cases treated with GnRHa(33.7%)suffered from dysmenorrhea, and there was no significant difference as compared with healthy girls and girls with early menarche. Conclusion The incidence of irregular menstruation was similar in early menarche girls and normal girls. CPP and EFP girls with GnRHa treatment had a significantly higher incidence of irregular menstruation than normal girls, but no difference was found as compared with girls with early menarche. Early menarche and GnRHa treatment did not affect the incidence of dysmenorrhea. (Chin J Endocrinol Metab, 2015, 31: 774-777) Key words: Early menarche; Central precocious puberty; Early and fast puberty; Gonadotropin-releasing hormone analogs; Menstrual regularity