Menstrual cycle and gynecologic pathology in menstrual-related migraine

E A Kiryanova,G R Tabeeva

doi:10.14412/2074-2711-2021-4-12-17

E A Kiryanova, G R Tabeeva

Open Access

https://doi.org/10.14412/2074-2711-2021-4-12-17

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Abstract

Migraine is the first most frequent cause of disability among women of reproductive age globally, and up to 60% of patients note the association of headache attacks with menstruation.Objective: to determine the features of menstrual cycle and gynecologic pathology in women with menstrual-related migraine (MRM).Patients and methods. A prospective comparative study included 69 women of reproductive age with a migraine diagnosis who did not receive hormonal contraception. Depending on the association of migraine attacks with menstruation (according to headache diaries), the patients were divided into two groups: the 1st group consisted of 44 patients with MRM; group 2 — 25 patients with non-menstrual migraine (without the association of attacks with menstruation).Results and discussion. Patients with MRM had heavier menstrual bleeding, longer menstruations (more than six days), abnormal menstrual cycle length and regularity, dysmenorrhea. In addition, the obtained data indicate a comorbid estrogen-associated gynecological pathology (endometriosis, adenomyosis, endometrial polyps, myoma) in MRM.Conclusion. Presumably, the hypothalamic-pituitary-ovarian axis dysfunction plays the leading role in the MRM. It presents with menstrual cycle abnormalities and increased presence of estrogen-associated gynecological pathology, which should be considered during patient evaluation and suggesting recommendations.

Highlights

Migraine is the first most frequent cause of disability among women of reproductive age globally, and up to 60% of patients note the association of headache attacks with menstruation
Depending on the association of migraine attacks with menstruation, the patients were divided into two groups: the 1st group consisted of 44 patients with menstrual-related migraine (MRM); group 2 – 25 patients with non-menstrual migraine
The hypothalamic-pituitary-ovarian axis dysfunction plays the leading role in the MRM. It presents with menstrual cycle abnormalities and increased presence of estrogen-associated gynecological pathology, which should be considered during patient evaluation and suggesting recommendations

Summary

ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИ

Цель исследования – определение особенностей менструальной функции и гинекологической патологии у пациенток с менструально-ассоциированной мигренью (МАМ). Для пациенток с МАМ характерны более обильные менструации, длительность менструального кровотечения свыше 6 дней, аномальные по длительности и регулярности менструальные циклы, дисменорея. The hypothalamic-pituitary-ovarian axis dysfunction plays the leading role in the MRM It presents with menstrual cycle abnormalities and increased presence of estrogen-associated gynecological pathology, which should be considered during patient evaluation and suggesting recommendations. В последние годы возрастает интерес к изучению особенностей менструальной функции при ММ, но в настоящее время доступны лишь результаты исследований, основанных на самодиагностике МАМ и НММ с помощью опросников, субъективного восприятия регулярности менструального цикла и, кроме того, включающих пациенток, которые принимают гормональные контрацептивы [8, 9].

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Findings

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