Abstract
There are suggestions that women have higher relative risks of lung cancer than men given similar levels of tobacco exposure, implying that sex-related hormones may influence lung cancer risk. We evaluated the association between lung cancer risk and menstrual and reproductive factors on a subset of self-responding females in a population based case-control study in Eastern Gansu Province, China, 1994-1998. The analysis included 109 incident lung cancer cases and 435 controls selected from the census list and frequency matched to cases on age and prefecture. Odds ratios were lower for later ages at menarche (trend, P = 0.015) and later ages at menopause (trend, P = 0.074). Despite limitations, these findings suggest a possible role of hormones in the etiology of lung cancer in females.
Highlights
There are suggestions that women have higher relative risks of lung cancer than men given similar levels of tobacco exposure, implying that sex-related hormones may influence lung cancer risk
We evaluated the association between lung cancer risk and menstrual and reproductive factors on a subset of self-responding females in a population based case-control study in Eastern Gansu Province, China, 1994-1998
These findings suggest a possible role of hormones in the etiology of lung cancer in females
Summary
Case-control study of incident lung cancer in males and females in Pingliang and Qingyang, two rural prefectures in Eastern Gansu Province, China, described in detail elsewhere.[24]. The panel considered all the available diagnostic evidence for the particular case, including medical records, radiological images, pathology reports and/or slides. Controls were randomly sampled from the population census list of the two prefectures and frequency matched to cases by gender, within 5-year age group and prefecture in a ratio of 2:1.24 A total of 455 female controls were eligible. Since controls were frequency matched on age, all 435 interviewed controls were included in the analysis. Unconditional, multivariate logistic regression models were carried out using the SAS program26to adjust ORs for confounding factors (reference age, prefecture, socioeconomic status, active smoking, environmental tobacco smoke among never-smokers, the amount of coal used in homes for cooking and heating, cooking oil use, and previous pulmonary diseases). Reference age was defined as the age at diagnosis for a case and the age at interview for a control.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
