Abstract
Background: This study aims to understand the relationship between menopausal status and the presence of Metabolic Syndrome in women from 40 to 65 years, as well as to describe the distribution of each component of Metabolic Syn- drome according to sample characteristics. Methods: A cross-sectional study was conducted with 551 women treated at a clinic in southern Brazil. MetS and its components were defined according to NCEP-ATP III and menopausal status as pre, peri, and post-menopause. Prevalences of menopausal status and of MetS and its components were calculated. Estimates of prevalence ratios crude and adjusted with confidence intervals of 95% were calculated by Poisson Regression with robust variance. Demographic, socioeconomic, behavioral, and reproductive characteristics were considered as potential confounding factors in multivariable models based on a conceptual framework of MetS determination. Results: The prevalence of Metabolic Syndrome in the sample was 56.1% (CI95%: 51.9 to 60.2), being more common among older women (56 to 65 years), with low education, menarche 11 years old, with three or more pregnancies and in the post-menopausal period. In multivariate analysis, there was an increase of prevalence ratios when comparing perimenopause and post-menopause with pre-menopause; however, the confidence intervals include the unit. Regarding the analysis of isolated components in the sample, the most prevalent altered components were: hypertension (84.8%; CI95%: 81.7 to 87.8), waist circumference (66.4%; CI95%: 62.5 to 70.4) and HDL cholesterol (51.7%; CI95%: 47.5 to 55.9). There was a linear increase on mean blood glucose through menopausal status. Conclusions: Our study indicates variation on the distribution of MetS and each component according to menopausal status and other women characteristics. Future studies on MetS should also have foresight to use this type of approach to improve understanding and targeting of actions and programs focusing on women in this period of life.
Highlights
Climacteric is defined as the period of transition from the reproductive stage to the non-reproductive stage
This study aims to understand the relationship between menopausal status and the presence of Metabolic Syndrome in women from 40 to 65 years, as well as to describe the distribution of each component of Metabolic Syndrome according to sample characteristics
The present study investigated the relationship between menopausal status and presence of Metabolic Syndrome in women from 40 to 65 years treated at a clinic of climacteric and Gynecological Surgery in southern Brazil
Summary
Climacteric is defined as the period of transition from the reproductive stage to the non-reproductive stage. The menopausal status is established according to the menstrual cycle characteristics or the time of amenorrhea, and can be divided into pre-menopause, perimenopause and post-menopause, based on the last menstrual period (menopause) [2]. This study aims to understand the relationship between menopausal status and the presence of Metabolic Syndrome in women from 40 to 65 years, as well as to describe the distribution of each component of Metabolic Syndrome according to sample characteristics. There was an increase of prevalence ratios when comparing perimenopause and post-menopause with pre-menopause; the confidence intervals include the unit. Conclusions: Our study indicates variation on the distribution of MetS and each component according to menopausal status and other women characteristics. Future studies on MetS should have foresight to use this type of approach to improve understanding and targeting of actions and programs focusing on women in this period of life
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