Meningiomas: A Clinicopathological study

Abstract

cells. Most of these tumors are intracranial; some are intraspinal and few extra cranial. There are many histological variants classified into three grades depending on clinical behavior. Classification is important for determining the modality of treatment. Objectives: To study the incidence, location, sex and age predilection, histological variants and grading of meningiomas based on WHO 2007 classification and recurrence if present. Materials and methods: All128 cases of meningiomas. Based on Histological features, typing and grading of meningiomas was done as per the WHO 2007 classification of Meningiomas. Age, Sex incidence, Location of meningiomas were studied. Results: Meningiomas comprised 25.25% of all CNS tumors during the study period. Of 507 CNS tumors, 128 were meningiomas. Most of them were intracranial, predominantly involving the convexities of brain, females and the 41 – 50 age group. Of these, 116 were benign grade I tumors, 9 were grade II and 3 were grade III. The most common histological variant was fibroblastic and meningothelial. Intraspinal meningiomas were 16 (12.5%) cases with the psammomatous variant being more common. Grade II and Grade III tumors located in parafalcine or parasagittal area commonly recurred. Conclusion: Meningiomas are slow growing tumors arising from the meningothelial cells accounting for 25.25% of all CNS neoplasms showing a variety of histological patterns, more common in women, predominantly Grade I tumors. Recurrence of tumors depends on histological grade and extent of surgery.