MENINGIOMA-03 FUNCTIONAL OUTCOME AFTER SURGERY FOR INTRACRANIAL MENINGIOMA AT THE KENYATTA NATIONAL HOSPITAL

Abstract

Abstract BACKGROUND Intracranial meningiomas represent 34.4% to 41.4% of all brain tumors at the Kenyatta National Hospital. Surgical outcomes have been asessed priviously by Simpson grade achieved at surgery, recurrence rates, rates of complication, overall and progression free survival amongst other surgical outcomes. The functional outcome that assess the performance of these patients in activities of daily life is a less studied outcome. BROAD OBJECTIVE This was a retrospective observational cross-sectional study to determine the functional outcome after surgery for intracranial meningioma among adult patients operated at the Kenyatta National Hospital MATERIALS AND METHOD Exposure data was collected on age, sex, extent of resection (Simpson grade) of intracranial Meningioma, and WHO grade of meningioma. Outcome data was the Functional Independent Measure. RESULTS 42 participants were enrolled, with an average age of 46.8 years and a male-to-female ratio of 1:4.25. Mean presentation was within 13.6 months with headaches 97.7% and seizures 41.9%. Average size of meningioma was 138.4 cm3, and perilesional edema was observed in 90.6% of cases. Surgical resection achieved a Simpson grade II in 52.4% of cases and Simpson grade I in 38.1% of cases. Histologic grade was commonly WHO grade 1 (95.2%), specifically the Meningothelial variant (61.9%). Functional status improved with a mean total gain of 161.9% in the Functional Independent Measure (FIM), a motor sub score gains of 174%, and a cognitive sub score gain of 149.6%. There was no statistically relevant association between the functional outcome and extent of surgical resection. CONCLUSION There was statistically significant improvement in the functional outcome after surgery for intracranial meningioma measured using the Functional Independence Measure. The Simpson grade achieved at surgery did not influence the functional outcome.