Meningioangiomatosis: One Sporadic Case Report and Literature Review

Abstract

Meningioangiomatosis is a rare condition, probably hamartomatous, characterized by proliferation of capillarysized vessels, meningothelial cells, and fibroblasts within the cortex of the brain. Lesions may be single in sporadic type or multiple in neurofibromatosis type II. Clinically, it presents with seizures but may be asymptomatic throughout life. A 16-year-old female experienced persistent headache, dizziness, nausea and seizure. The brain magnetic resonance imaging showed a mass at right anterior-inferior temporal lobe sized around 3 x 3 cm. The tumor was located in the cerebral cortex to the leptomeninges base on the operative finding. The lesion was characterized by a plaque-like proliferation of meningothelial and fibroblast- like cells surrounding small vessels arranged in a fascicular pattern and diffused concentric and laminated calcified nodules. Immunohistochemically, the spindle-shaped cells had a moderate to strong positivity to vimentin and CD34 and negative to epithelial membrane antigen, S-100 and smooth muscle actin protein.Since this condition is rare, close clinico-pathological correlation is essential. A correct diagnosis avoids further aggressive treatments. We report this rare case and review of the literature.