Abstract
Meningeal melanocytoma is a rare type of benign pigmented tumor of the central nervous system that derives from leptomeningeal melanocytes, which originate from the neural crest. These tumors are commonly focal, but there are descriptions of multifocal forms in the literature, and reports of malignant transformation, with leptomeningeal dissemination. In this paper, a case of meningeal melanocytoma with leptomeningeal dissemination is reported and, based on a review of the literature, comments on the diagnostic and therapeutic difficulties relating to this disease are made.
Highlights
Meningeal melanocytoma (MM) is a rare type of tumor of the central nervous system (CNS) that comes from leptomeningeal dendritic melanocytes, which embryologically originate from the neural crest
Melanocytes in the CNS are usually found at the base of the brain, in the brainstem and in the spinal cord
We present a clinical case of a young patient with the leptomeningeal form of MM, and discuss the diagnostic and therapeutic aspects of this rare neoplasm
Summary
Meningeal melanocytoma (MM) is a rare type of tumor of the central nervous system (CNS) that comes from leptomeningeal dendritic melanocytes, which embryologically originate from the neural crest. In a second surgical procedure, he underwent a biopsy on one of these lesions, which was accessible in the region of the left sylvian fissure, with removal of rare blackened material of vascular nature. This material was suggestive of hemangioblastoma grade I. In the dorsal/lumbar region, anomalous intradural and extra-medullary material was seen, especially in a posterior position, involving the entire length of the thoracic spinal cord This material took on a nodular format at the level of the conus medullaris (Fig. 2). This case report was approved by the Ethics Committee of Hospital Santa Rosa (protocol number: 01/2011), and the patient gave her consent for publication
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