Abstract
Mendelian randomization (MR) approach is based on the Mendelian genetic law, which is called "Parental alleles that randomly assigned to the offspring" . MR refers to the use of genetic variants to develop causal inferences from observational data, if the variant genotype is associated with the phenotype and the variant genotype associated with the risk of disease of interest through the phenotype. Hence, the genotype can be used as Instrumental Variable (IV) to infer the causal relation between the phenotype and the risk of diseases. In recent years, MR approach is widely used in causal inference between the exposure factors and the risks of disease, along with the rapid development of statistical methods, big datasets of GWAS, epigenetics and the various "omics" techniques. This paper provides an overview of the MR strategies and addresses the related assumptions and implications, with reliability and limitations included.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
