Abstract
A considerable amount of menaquinone (MK)-4 was found in cells of a 1-hydroxy-2-naphthoate-resistant mutant, strain HNA 250-15, which was derived from Flavobacterium sp. 238-7, in which MK-6 is the major isoprenoid quinone. The MK-4 productivity was further improved by making the mutant resistant to usnic acid and menadione. The amount of MK produced by the resultant mutant, strain K3-15, produced 125.4mg/l of culture broth and 12.8mg/g of dry cell weight, in the ratio of MK-4 and MK-6 of 6:1, under the optimal culture conditions in the presence of cedar wood oil.
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