Abstract
We demonstrate a hyperspectral and depth sensitive diffuse optical imaging microsystem, where fast scanning is provided by a CMOS compatible 2-axis MEMS mirror. By using lissajous scanning patterns, large field-of-view (FOV) of 1.2cm x 1.2cm images with lateral resolution of 100µm can be taken at 1.3 frames-per-second (fps). Hyperspectral and depth-sensitive images were acquired on tissue simulating phantom samples containing quantum dots (QDs) patterned at various depths in Polydimethylsiloxane (PDMS). Device performance delivers 6 nm spectral resolution and 0.43 wavelengths per second acquisition speed. A sample of porcine epithelium with subcutaneously placed QDs was also imaged. Images of the biological sample were processed by spectral unmixing in order to qualitatively separate chromophores in the final images and demonstrate spectral performance of the imaging system.
Highlights
The clinical need for noninvasive skin cancer detection devices has led to intensive commercial and research efforts to develop novel instruments for imaging, spectroscopy or the combination of both [1]
We demonstrate a hyperspectral and depth sensitive diffuse optical imaging microsystem, where fast scanning is provided by a CMOS compatible 2-axis MEMS mirror
By using lissajous scanning patterns, large field-of-view (FOV) of 1.2cm x 1.2cm images with lateral resolution of 100μm can be taken at 1.3 frames-per-second
Summary
The clinical need for noninvasive skin cancer detection devices has led to intensive commercial and research efforts to develop novel instruments for imaging, spectroscopy or the combination of both [1]. Portable hyperspectral screening devices are highly desirable for the sensitive, biopsy-free characterization of diseases in situ and precision guided microsurgery. This will prevent the costly millions of unnecessary biopsies performed every year, and to make the diagnosis and treatment for diseases like melanoma more convenient and timely. While SDx provides detailed physiological data that can be useful for diagnosis, it does not allow for mapping or imaging of skin sites
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