MEMS Biosensor Design and Simulation for Diagnostic Purposes

Abstract

A Biosensor is a device detects a chemical substance that combines a biological component. Micro cantilevers are used as sensors, transducers, probes, needles, transport mechanisms, resonators, latches, switches, and relays. The main concept in bio sensing application is antigen-antibody binding. When the magnitude of the force exerted is small, the sensitivity of the micro cantilever becomes high, so that the device can sense the presence of antigen even if the magnitude of the surface stress over the cantilever is very small. With the help of COMSOL Multi-Physics, micro-cantilever is designed as MEMS biosensors that diagnose various diseases accurately and rapidly when compared to other techniques. This biosensor is capable to detect HBV and N1H1 by immobilizing particular antibodies on the surface of the cantilever. The Moment the patient samples are sensed by sensors sensing element contains antigen; biochemical interactions found on the sensing part. Biochemical interactions occur between the antigens of HBV, H1N1, and the antibodies attached to the sensing element’s surface; as a result, the diseases are detected. In the current paper dual cantilever is designed for diagnosing two diseases in single step at the same time accurately. Here the cantilever can sense even a minute deformation 1.6x10-06 mm, hence it can be applied in designing MEMS based biosensor for diagnostic purpose. The dual-beam cantilever is simulated by choosing a suitable polymer to fabricate biosensor to detect swine flu and jaundice with the help of COMSOL Multi physics.