Abstract
Twenty one cases of ALL (13 males, 8 females) were analysed for the presence of T and B membrane markers in blood or bone marrow prior to treatment. Their ages were between 2 and 16 years. E rosettes with SRECs(at 48 and 37° C) and with autologous RBCs, HEA and HEAC rosettes were performed. The surface imnunoglobulins(with monospecific antisera to μ, γ and α chains) were detected by using a direct immunofluorescence technique. Seven(33%) were T cell;l (4%) was B cell; and 13(62%) were considered to be null cell type. The male:female ratio was 5:8 in null cell; 7:0 in T cell type. Two cases of T cell type had mediastinal lymphadenopathy. There was no significant difference for the WBC counts between the T and null cell groups. During the first 6 weeks of treatment, 50% of the patients with T cell type and 10% of the patiants with null cell type did not go into remission with classical induction therapy. Forty-two percent of bhe patients with T cell type and 7% of the patients with null cell type had CMS infiltration. Forty-two percent of the patients with T cell type and 12% of the patients with null cell type lied during the observation period of this study.
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