Abstract
This study investigated the role of underlying pathology on memory function of children with temporal lobe epilepsy (TLE). Memory was assessed in 44 children with TLE resulting from hippocampal sclerosis (HS) or dysembryoplastic neuroepithelial tumours (DNT), and 22 control children. Delayed story and paired associate recall performance was significantly more impaired in children with HS compared to those with DNT, irrespective of the affected side. Semantic memory was impaired in both HS groups, and also in the left DNT group. These results suggest a role for type, and to a lesser extent, side of pathology in the memory profile of children with TLE.
Highlights
In adults, left temporal lobe epilepsy (TLE) is associated with deficits in remembering verbal material (Helmstaedter and Elger, 1998; Helmstaedter et al, 1997)
We predicted that verbal declarative memory function, i.e. episodic and semantic memory, would be affected differently by pathology type (Jambaqué et al, 2007; Helmstaedter and Elger, 1998)
Semantic memory was more impaired in those with left sided pathology (F(1,39) = 6.0, p = 0.019), and there was a significant interaction between type and side of pathology (F(1,39) = 4.1, p = 0.05), indicating that RDNT cases were the only group not to show a deficit (Fig. 2).The semantic memory deficit is consistent with previous data from adults (Giovagnoli et al, 2005) and children (Jambaqué et al, 2007; Rzezak et al, 2011), and the role of the anterior temporal lobe in semantic memory (Giovagnoli et al, 2005)
Summary
Left temporal lobe epilepsy (TLE) is associated with deficits in remembering verbal material (Helmstaedter and Elger, 1998; Helmstaedter et al, 1997). There is some evidence that HS and lesional pathology have different effects on declarative memory in adults (Helmstaedter and Elger, 1998; Helmstaedter et al, 1997). Such differential effects have not been consistently replicated in children (Gonzalez et al, 2007; Nolan et al, 2003), due perhaps to. We predicted that verbal declarative memory function, i.e. episodic and semantic memory, would be affected differently by pathology type (Jambaqué et al, 2007; Helmstaedter and Elger, 1998). Relationships between continuous variables were analysed with Pearson’s correlation coefficient
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