Abstract
Thespesia populnea. Soland ex. Correa (Malvaceae) is a large tree found in the tropical regions and coastal forests of India. Various parts of Thespesia populnea. are found to possess useful medicinal properties such as antifertility, antibacterial, anti-inflammatory, antioxidant, purgative, and hepatoprotective activities. The current study was undertaken to investigate the effects of Thespesia populnea. bark on memory in rats. Elevated plus-maze and Hebb-Williams maze served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine-, and ageing-induced amnesia served as the interoceptive behavioral models. The ethanol extract of Thespesia populnea. (TPE) was administered orally in three doses (100, 200, and 400 mg/kg) for 7 successive days to different groups of young and aged rats. TPE (200 and 400 mg/kg, p.o.) resulted in significant improvement in memory of young and aged rats. TPE also reversed the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Cholesterol-lowering, anticholinesterase, anti-inflammatory, and antioxidant properties of Thespesia populnea. may favorably contribute to its memory-enhancement effect. Therefore, Thespesia populnea. bark appears to be a promising candidate for improving memory, and it would be worthwhile to explore the potential of this plant in the management of Alzheimer patients.
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