Meme Kanserinde Oksidatif Stresin Prognostik Değeri ve Önemi

Abstract

Objective: The aims of this study were to investigate Total Antioxidative Status (TAS), Total Oxidative Status (TOS), and Oxidative Stress Index (OSI) levels in breast cancer patients and compare them to levels in healthy women.Materials and Methods: In the study, 45 breast cancer patients and 46 healthy women participated. The OSI value was calculated as the % ratio of the TAS and TOS values. The data were analyzed on IBM SPSS 21.0 package software.Results: When the mean TOS values in patients and healthy women were compared, the control group had a TOS of 3.44 µ mIU/L and the patient group had a TOS of 11.93 µ mIU/L. TAS was found to have a mean value of 1.74 µ mIU/L in the control group and 1.63 m/mol/L in the patient group. OSI was determined to have a mean value of 7.23 in patients with breast cancer and 1.99 in healthy women. In female patients with breast cancer, TOS value was higher, TAS value was lower, and OSI value was significantly higher than healthy women (p<0.01).Conclusion: TOS, TAS and OSI values ​​can be a marker that can be used to differentiate patients with breast cancer and healthy women.