Abstract
The membranotropic and relaxation properties of novel water-soluble gadolinium endometallofullerene derivatives (EMFD) were studied. Localization of EMFD in membranes and EMFD-induced changes in the membrane structure were determined by measuring the emission quenching of pyrene as a fluorescent probe. It was demonstrated that EMFD efficiently interact with pyrene molecules in model membranes, thus changing their microviscosity. Pulsed 1H NMR experiments revealed that the hydroxylated endometallofullerene Gd@C82(OH)∼30 has the highest relaxivity (R1 = 7.390 L mol−1 s−1) among the test EMFD and that its efficiency is 3.6 times that of the commercial MRI contrast agent Magnevist. The data obtained suggest that these EMFD are promising for use as low-toxicity contrast agents for magnetic resonance imaging.
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