Membranotropic activity of taurine derivatives

Abstract

The aim of the work. To evaluate the effect of n-phenylalkyl derivatives of taurine on changes in transmembrane ion currents of potential-controlled ion channels of isolated neurons.
 Materials and methods. The method of intracellular dialysis and fixation of membrane potential on isolated neurons of the great pond truncatula (Lymnaea stagnalis) and hornbill (Planorbarius corneus) was used. The n-phenylalkyl derivatives of taurine (1-phenyl-2-isopropylaminoethanesulfonic acid; benzylaminoethane sulfonic acid isopropylamide; phenethylaminoethane sulfonic acid isopropylamide) or the comparison drug taurine was dissolved in external solutions and studied at concentrations of 1, 10, 100 and 1000 M.
 Results. The results demonstrate that n-phenilalkyl derivatives of taurine in low concentrations (1; 10 M) have a modulating effect on electrically excitable cells, and in high concentrations (100; 1000 M) reduce the sodium-calcium influx and potassium efflux ionic currents, have a channel blocking effect.
 Conclusion. N-phenylalkyl derivatives of taurine reduces the excitability of cells contribute to the suppression of synaptic potentials, ion gradients of the cells.