Abstract
In epithelial sheets, processes that drive cells to change topological relationships can be harnessed by developmental mechanisms to effect changes in tissue architecture. Organisms ranging from humans to Drosophila lengthen their anterior-posterior axis during development. An essential driver of tissue elongation is oriented cell intercalation. In the Drosophila embryonic epithelium, individual cells are able to either consolidate cell-cell contacts or direct neighbor exchange movements through the asymmetric localization of cell adhesion and polarity proteins.
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