Abstract
The insertion and assembly of integral membrane proteins into biological membranes is an important and largely uncharacterized process in many organisms. Studies using Escherichia coli have elucidated the roles of certain amino acids in determining the topology of integral membrane proteins. However, the role of the environment in which the protein sits – the phospholipid bilayer – has been largely ignored in these studies. Now, William Dowhan and his group in Houston, USA, have made some exciting observations relating membrane lipid composition to the topology of a well-studied integral membrane protein [ 1. Bogdanov M. et al. A polytopic membrane protein displays a reversible topology dependent on membrane lipid composition. EMBO J. 2002; 21: 2107-2116 Crossref PubMed Scopus (190) Google Scholar ].
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