Abstract
In previous studies of the release of cytoplasmftlled microvesicles from human red blood cells either during storage [ 1,2] or following treatment with Cap and the ionophore A23 187 [3] we have frequently observed slender protuberances (‘tails’) on many of the vesicles, but we have been uncertain whether they represented a genuine feature of microvesicle structure or an artefact of preparation for electron microscopy. The reality of these structures has now been confirmed using a variety of preparative techniques for electron microscopy and they have been isolated and their lipid and polypeptide composition determined. The results indicate that during microvesicle formation there is segregation of membrane proteins, and that this segregation occurs in two stages.
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