Membrane potential reconstruction, based on extracellular potential measurements

Abstract

Event Abstract Back to Event Membrane potential reconstruction, based on extracellular potential measurements Z. Somogyvári1*, L. Wittner2, I. Ulbert2 and P. Érdi3 1 KFKI Research Institute for Particle and Nuclear Physics of the Hungarian Academy of Science, Hungary 2 Institute for Psychology of the Hungarian Academy of Science, Hungary 3 Kalamazoo College, Center for Complex System Studies, United States Is it possible to reconstruct the membrane potential based on extracellular (EC) potential measurements? We have developed a three-step model based method to reach this aim and showed the existence of this possibility in simulated data. In the first step, the spike CSD (sCSD) method was used to reconstruct the spatio-temporal distribution of the single cell current source density from the EC potential patterns. We have shown, that the CSD calculated from the EC potential, does not correspond to the total membrane current. Thus, we have introduced a second step of the analysis, a model-based spatio-temporal deconvolution to reconstruct the spatio-temporal distribution of the net membrane current from the CSD distribution. Finally, the membrane potential was reconstructed by using a current-based compartmental model. The procedure depends on the appropriate modeling of the morphological and passive cable properties of the neuron. Finally, we have tested the new method by comparing the results of simultaneous intracellular recordings to the reconstructed membrane potential based on EC potential recordings with micro electrode array. Keywords: Neurophysiology, Neuroscience Conference: 13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011. Presentation Type: Abstract Topic: Neurophysiology Citation: Somogyvári Z, Wittner L, Ulbert I and Érdi P (2011). Membrane potential reconstruction, based on extracellular potential measurements. Front. Neurosci. Conference Abstract: 13th Conference of the Hungarian Neuroscience Society (MITT). doi: 10.3389/conf.fnins.2011.84.00033 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2011; Published Online: 23 Mar 2011. * Correspondence: Dr. Z. Somogyvári, KFKI Research Institute for Particle and Nuclear Physics of the Hungarian Academy of Science, Budapest, Hungary, soma@mail.kfki.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Z. Somogyvári L. Wittner I. Ulbert P. Érdi Google Z. Somogyvári L. Wittner I. Ulbert P. Érdi Google Scholar Z. Somogyvári L. Wittner I. Ulbert P. Érdi PubMed Z. Somogyvári L. Wittner I. Ulbert P. Érdi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.