Abstract
Type I cells of embryonic rabbit carotid bodies were cultured under normoxic (21% O 2, 10% CO 2, 69% N 2) and hypoxic (5% O 2, 10% CO 2, 85% N 2) conditions for two days. The mean membrane potential in the hypoxic cultivated type I cells (−27 mV) was significantly higher than in normoxic cultivated cells (−10 mV). The mean input resistance also had the tendency to increase under hypoxic conditions, from 19 mΩ to 48 MΩ. Results suggest that variations in membrane potential of type I cells due to oxygen pressure changes are an expression of the important role of these cells in oxygen sensing by the carotid body.
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