Abstract

Current view about cell is that the cell is a watery solution coated with semi-permeable membrane and there exists nonzero potential, so-called membrane potential, across the semi-permeable cell membrane. Goldman-Hodgkin-Katz equation and Donnan theory are the fundamental existing theories for explaining the cause of membrane potential generation. However, the observations of membrane potential inexplicable by these existing theories have been repeatedly reported by a small number of researchers for more than the past half century. Hence, it is needless to say important to reconsider the membrane potential generation mechanism. Based on the experimental result shown in this paper, it was concluded that the existing theories were not genuinely right for the explanation of membrane potential generation. Adsorption theory is only a genuinely right theory instead. The adsorption theory describes that the adsorption of the mobile ions on the adsorption sites on the membrane generates the membrane potential. This work introduces the experimental observation inexplicable by Goldman-Hodgkin-Katz equation or Donnan theory but is in harmony with the adsorption theory.

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