Abstract

ANALYSIS of membrane noise in excitable membranes may yield information about the kinetics governing the conductance control of various ionic channels. Such analysis has been applied to noise arising from conductance fluctuations in, for example, the potassium system1,2 or the system of postsynaptic ionophores3,4. This report deals with noise that seems to be generated in the sodium channel of the slowly adapting stretch receptor neurone of lobster. We recorded this noise as current noise under voltage clamp, and subsequently analysed it with respect to its covariance and spectral density function. A particularly low degree of Na inactivation at polarisations down to firing threshold was inferred from these analyses.

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