Abstract
This historic review of membrane inlet (or membrane introduction) mass spectrometry, MIMS, covers the scientific development of MIMS from initially a method for the analysis of atmospheric gases dissolved in water to a well-established field-portable technique for the analysis of volatile and semi-volatile organic compounds from solid, liquid, and gaseous samples without sample pretreatment. The path to the modern field-portable instruments went through three major research areas: in vivo probes for the analysis of blood gases (1960–1980), on-line monitoring of fermentations (1975–1995), and detection of contaminants in environmental samples (1990 and onwards).
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