Abstract
Iontophoretic injections of inositol 1,4,5-trisphosphate inside neuroblastoma × glioma NG108-15 hybrid cells evoked an outward K + current across the outer cell membrane, probably activated by the release of intracellular Ca 2+. No such current was produced by equivalent intracellular injections of inositol 1,3,4-trisphosphate or inositol 1,3,4,5-tetrakisphosphate. Instead, these compounds evoked an inward current with a reversal potential of about −20 mV, and which may therefore be due to a non-specific cation conductance. This suggests that these derivatives are unable to release sufficient Ca 2+ to activate the Ca 2+-dependent K + current in these cells.
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