Abstract
The effect of viruses on the surface membrane of susceptible cells during the entry and exit process has been studied. Haemolytic paramyxoviruses induce a non-specific leakage to low-molecular-weight compounds during entry; other viruses do not show this effect. During exit, no such changes occur with any virus so far studied: some viruses are released without any obvious change at all in surface membrane function; in other cases, uptake of some nutrients is altered and there is a fall in membrane potential. These results do not support the hypothesis that a generalized membrane leakiness is a prerequisite for the synthesis and release of virus particles.
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