Abstract
The patients described in this report used medications thatcould cause cognitive impairment. Memantine could haveantagonized these effects, through unclear mechanisms.To our knowledge, this is the first report on the usefulness ofmemantine in the treatment of cognitive impairment in bipolardisorder patients. Randomized double-blind controlled studies areneeded to validate these preliminary observations.Chei Tung TengClinical Hospital, Medical School, Group of AffectiveDiseases and Liaison Psychiatry Group, Institute of Psychiatry,Universidade de Sao Paulo (USP), Sao Paulo (SP), BrazilFrederico Navas DemetrioClinical Hospital, Medical School and ambulatory of theGroup of Affective Diseases, Universidade de Sao Paulo (USP),Sao Paulo (SP), Brazil
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