Abstract
AbstractOver the past two decades, Meltrex® has evolved from being a novel processing technique into a comprehensive manufacturing technology. This chapter discusses the successful application of Meltrex® in the commercial development of delivery systems for varied drugs such as lopinavir (Kaletra®), ritonavir (Norvir®), ibuprofen, and verapamil hydrochloride (Isoptin®). Besides the commercial applications, Meltrex® can be successfully applied in design of solid dispersions (bioavailability enhancement of poorly soluble drugs), alter or control dissolution profiles (sustained release), reduced dosing frequency, deter substance abuse, improve safety, and efficacy of drugs. Moreover, continuous processing, rigorous and comprehensive regulatory documentation, and use of generally regarded as safe (GRAS) material are some of the striking features which make Meltrex® a popular drug delivery technology.KeywordsSolid DispersionArea Under CurveTablet FormulationAmorphous Solid DispersionSustained Release FormulationThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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