Abstract
Curcumin-loaded poly (ε-caprolactone) (PCL) fibres prepared by melt and solution electrospinning methods were both fabricated to investigate their difference in characterization and drug release behaviour. The increasing curcumin content did not influence the morphologies of melt electrospun fibre, but enhanced the range of diameter distribution of solution electrospun fibre owing to the curcumin aggregates in the spinning solution which disturbed the stability of jet. Moreover, a large amount of curcumin with amorphous state could be loaded in the melt electrospun fibre. Whereas the limited solubility of curcumin in the solvent led to the drug aggregates dispersing within the solution electrospun fibre. In addition, the melt electrospun fibres had low drug release rate without burst release on the profiles due to the high crystallinity in the fibre, but high drug release rate and burst release occurred on the release profiles of the solution electrospun fibres because of their low crystallinity, porous structure and roughness surface.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
