Melphalan plus Stem-Cell Transplantation Improves Kidney Function in Patients with Primary Amyloidosis

Abstract

Summaries for Patients1 May 2001Melphalan plus Stem-Cell Transplantation Improves Kidney Function in Patients with Primary AmyloidosisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-9_Part_1-200105010-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Primary (AL) amyloidosis is an uncommon condition in which abnormal bone marrow cells make proteins that form thin bands or fibrils of a substance called amyloid. The amyloid fibrils can settle in many organs of the body and lead to organ failure and death. One of the most common organs affected is the kidney. Patients with kidneys affected by amyloid typically lose large amounts of protein in their urine because the amyloid interferes with the filtering mechanism of the kidney. These patients can eventually develop kidney failure and ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Effect of Dose-Intensive Intravenous Melphalan and Autologous Blood Stem-Cell Transplantation on AL Amyloidosis–Associated Renal Disease.” It is in the 1 May 2001 issue of Annals of Internal Medicine (volume 134, pages 746-753). The authors are LM Dember, V Sanchorawala, DC Seldin, DG Wright, M LaValley, JL Berk, RH Falk, and M Skinner.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. Previousarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffect of Dose-Intensive Intravenous Melphalan and Autologous Blood Stem-Cell Transplantation on AL Amyloidosis–Associated Renal Disease Laura M. Dember , Vaishali Sanchorawala , David C. Seldin , Daniel G. Wright , Michael LaValley , John L. Berk , Rodney H. Falk , and Martha Skinner Effect of Dose-Intensive Intravenous Melphalan and Autologous Blood Stem-Cell Transplantation on AL Amyloidosis–Associated Renal Disease Laura M. Dember , Vaishali Sanchorawala , David C. Seldin , Daniel G. Wright , Michael LaValley , John L. Berk , Rodney H. Falk , and Martha Skinner Metrics 1 May 2001Volume 134, Issue 9_Part_1Page: I-91KeywordsAmyloid proteinsAmyloidosisBone marrowBone marrow cellsChemotherapyKidneysRenal transplantationStem cellsTransplantationUrine ePublished: 1 May 2001 Issue Published: 1 May 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...