Abstract
The use of nanohybrids containing cationic or anionic inorganic compounds, seems particularly promising as efficient strategy for drug delivery. In fact, the inorganic counterions usually present in the host can be easily exchanged with drug molecules, from antitumor to anti-inflammatory, antibiotics and vitamins, giving rise to composites with improved solubility. An interesting inorganic host emerging for different applications, from catalysis to water purification up to pharmaceutics, is the layered double hydroxide (LDH) possessing a sheets structure and formula [$${\text{M}}_{{1 - {\text{x}}}}^{2 + }$$$${\text{M}}_{\text{x}}^{3 + }$$ (OH)2](An−)x/n yH2O (M2+ = Zn, Mg; M3+ = Al; An− = nitrates, carbonates, chlorides). In this paper, we synthesize by co-precipitation and reconstruction methods the hybrid compound Meloxicam-Zn3Al-LDH, particularly useful for a poorly soluble anti-inflammatory drug. The effective drug intercalation into LDH was verified through X-ray powder diffraction, thermal measurement and infrared spectroscopy. In addition, microscopy/microanalysis supported the formation of new entities. The dissolution tests clearly demonstrate an amazing improvement of the drug release rate with respect to marketed compounds when meloxicam is in the form of hybrid compound.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Journal of Inorganic and Organometallic Polymers and Materials
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.