Abstract
Meloxicam, a non-steroidal anti-inflammatory drug acting on the principle of cyclooxygenase-2 inhibition and having an improved side-effect profile in terms of the gastrointestinal toxicity, has been found to stimulate hematopoiesis in whole-body sub-lethally or mid-lethally gamma-irradiated mice. Studies on mechanisms of the hematopoiesis-stimulating action of meloxicam have revealed elevated serum levels of granulocyte colony-stimulating factor (G-CSF) within the interval of 24 hours after the administration of the drug. Induction of production of G-CSF may be, thus, supposed to be at least partially responsible for the observed beneficial effects of meloxicam in mice with radiation-induced myelosuppression. This work was supported by the Grant Agency of the Academy of Sciences of the Czech Republic (Grant No. 1QS500040507).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.