Abstract
Melodic intonation therapy (MIT) is a melodic musical training method that could be combined with language rehabilitation. However, some of the existing literature focuses on theoretical mechanism research, while others only focus on clinical behavioral evidence. Few clinical experimental studies can combine the two for behavioral and mechanism analysis. This review aimed at systematizing recent results from studies that have delved explicitly into the MIT effect on non-fluent aphasia by their study design properties, summarizing the findings, and identifying knowledge gaps for future work. MIT clinical trials and case studies were retrieved and teased out the results to explore the validity and relevance of these results. These studies focused on MIT intervention for patients with non-fluent aphasia in stroke recovery period. After retrieving 128 MIT-related articles, 39 valid RCT studies and case reports were provided for analysis. Our summary shows that behavioral measurements at MIT are excessive and provide insufficient evidence of MRI imaging structure. This proves that MIT still needs many MRI studies to determine its clinical evidence and intervention targets. The strengthening of large-scale clinical evidence of imaging observations will result in the clear neural circuit prompts and prediction models proposed for the MIT treatment and its prognosis.
Highlights
Aphasia is a language disorder generally caused by stroke-related damage to the dominant hemisphere
This review summarizes all Melodic intonation therapy (MIT) studies with non-fluent aphasia patients since 1970 (Table 1)
Since MIT was established in the 1970s as a more effective supplementary treatment for nonfluency aphasia, clinical trials on MIT have gradually garnered widespread attention
Summary
Aphasia is a language disorder generally caused by stroke-related damage to the dominant hemisphere. It describes a multitude of acquired language impairment as a consequence of brain damage (Go et al, 2014; WHO, 2015; Benjamin et al, 2017; Koleck et al, 2017). Oral expression of non-fluent aphasia is characterized by low speech volume, lack of grammar, and pronunciation dysphonia. According to the American Hearing Language Association’s classification of aphasia, the types of non-fluent aphasia include motor aphasia, complete aphasia, transcortical motor aphasia, and transcortical mixed aphasia (Kim et al, 2016; Gerstenecker and Lazar, 2019; Hoover, 2019). According to the survey data from WHO on stroke prevention in 2019, about 2.6 to 4.7 million
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