Abstract
The present investigated chemical composition of Melissa officinalis L. essential oil (MOEO) extracted by hydrodistillation. The MOEO was analyzed by gas chromatography-mass spectrometry (GC-MS), revealing the presence of thirty compounds, representing 98.46% of the oil constituents. The predominant components were 1,8-cineole (39.80%) followed by citronellol (16.66%), geraniol (12.25%), myrcene (5.85%) and geranial (5.45%). The antioxidant potential of MOEO has been summarized using DPPH test (IC50), superoxide anion (O2−·) scavenging activity (IC50), β-carotene (IC50) and reducing power (FRAP) (EC50). Results demonstrate strong scavenging superoxide anion capacity and moderate to weaker activity against the other assays. Potent inhibitory effect has been observed towards Micrococcus luteus and Bacillus cereus as well as the Candida albicans ATCC 90028, C. tropicalis (Strain 1) and C. albicans (Strain 8). Our work provides a view for the further studies on the antioxidant and antimicrobial of the MOEO and its main components.
Highlights
The Melissa officinalis L. essential oil (MOEO) was analyzed by gas chromatography-mass spectrometry (GC-MS), revealing the presence of thirty compounds, representing 98.46% of the oil
Our work provides a view for the further studies on the antioxidant and antimicrobial of the MOEO and its main components
Essential oils are a complex matrix composed of various volatile compounds which have been recognized for a long time as a powerful reservoir of therapeutic and pharmacological effect with health and nutritional benefits [1,2,3]
Summary
Essential oils are a complex matrix composed of various volatile compounds which have been recognized for a long time as a powerful reservoir of therapeutic and pharmacological effect with health and nutritional benefits [1,2,3] They have been explored as new alternatives in the development of cosmetics and pharmaceuticals products mainly due to their antioxidant and antimicrobial properties. The high and spread invasive of bacterial and fungal infections, as well as the increasing of drug resistance, accelerate the need for new antioxidants and antimicrobials to overcome infections disease [6,7,8] Those from natural product remains the most requested due to their low side effects [9,10,11,12,13,14]. Studies suggested that the high pharmacological capacity of this plant is mainly related to its richness in secondary metabolites such as flavonoids, phenolic acid, and terpenes [22]
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