Abstract
ABSTRACTWe describe a case series of seven culture proven melioidosis patients presenting during 2014 to 2016 in Madurai, south Tamilnadu. Skin, soft tissue, bone and joint infections were common. All of them were middle aged men except one case. All the cases were reported during the monsoon season. Predisposing factors include diabetes and alcoholism. Despite many case reports and studies from South India, melioidosis still remains undiagnosed, hence under reported from many centers. Delayed diagnosis leads way to sepsis and other complications. Awareness about the preventive measures, earlier clinical and laboratory identification and appropriate management of severe sepsis are required to reduce the burden of this disease.How to cite this articleGanesan V, Sundaramoorthy R et al., Melioidosis-Series of Seven Cases from Madurai, Tamil Nadu, India. Indian J Crit Care Med 2019;23(3):149-151.
Highlights
Melioidosis is an emerging infectious disease of major public health concern in southeast Asia
We describe a case series of melioidosis patients presenting during 2014 to 2016 in south Tamilnadu
All the isolates were sensitive to cotrimoxazole, Doxycycline, ceftazidime, piperacillin tazobactam and meropenem
Summary
Melioidosis is an emerging infectious disease of major public health concern in southeast Asia. We describe a case series of melioidosis patients presenting during 2014 to 2016 in south Tamilnadu. The pus culture showed lactose fermenting pink colonies in MacConkey’s agar on 1st day which turned dry and wrinkled on day 2 (Figure 1). The organism was confirmed to be B. pseudomallei by the above mentioned culture characteristics and standard biochemical methods (positive oxidase and nitrate reduction test, nonfermenting reaction with triple sugar Iron agar, hydrolyse arginine, oxidise glucose and lactose). The comorbid risk factors for melioidosis contribute by impairing neutrophil function. The function still deteriorates during acute and chronic hyperglycemic states. Such type of defects are observed in association with high alcohol consumption, chronic renal failure and thalassemia.
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