Abstract
Burkholderia pseudomallei is the etiological agent of melioidosis. It is a gram-negative bacillus present in environment and intrinsically resistant to many antibiotics including aminoglycosides. However, recently aminoglycoside susceptible B. pseudomallei has been isolated from melioidosis cases and reported from some countries of the world. But, such aminoglycoside susceptible B. pseudomallei has never been detected in Bangladesh either from melioidosis cases or from environment. All the B. pseudomallei isolated so far in Bangladesh were resistant to gentamicin and other aminoglycosides. Here, we describe a disseminated case of melioidosis caused by aminoglycoside susceptible B. pseudomallei in a 55 years old Bengali male patient. This is the first case of melioidosis due to aminoglycoside susceptible B. pseudomallei in Bangladesh.
 Ibrahim Med. Coll. J. 2020; 14(2): 55-59
Highlights
Burkholderia pseudomallei, a gram-negative bacillus, causing melioidosis is intrinsically resistant to aminoglycosides, macrolides and colistin [1,2]
Here we describe a disseminated case of melioidosis caused by aminoglycoside susceptible B. pseudomallei in a 55 years old Bengali male patient
All B. pseudomallei that have been isolated in Bangladesh till were resistant to amikacin and gentamicin by both Kirby-Bauer disk diffusion and MIC method [7]
Summary
Burkholderia pseudomallei, a gram-negative bacillus, causing melioidosis is intrinsically resistant to aminoglycosides, macrolides and colistin [1,2]. This intrinsic resistance to aminoglycosides and colistin is used as identification criterion for B. pseudomallei. Recently aminoglycoside susceptible B. pseudomallei strains have been detected in some regions of Malaysia, Thailand and Australia [3,4,5,6]. Such aminoglycoside susceptible B. pseudomallei has so far not been detected in Bangladesh.
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