Abstract
AbstractMelatonin—a tiny tryptophan derivative in the bovine pineal extract. Since then, this wonder molecule is known to regulate a wide variety of physiological and psychological activities of lower and higher vertebrates including the human beings. The exact mechanisms of melatonin actions are poorly understood and explained to date, but the coexistence of endocrine, paracrine, autocrine, and intracrine actions and feedback effects are suggested mostly to be mediated by the specific receptors found in the respective target organs. Melatonin exhibits a remarkable contextual diversity of functions as circadian pacemakers, hypothalamic/pituitary axes to vasomotor effects, immunomodulatory, antioxidative actions, anti-apoptotic effects (direct and indirect), etc. Melatonin with such efficacy and safety may therefore eventually drive its use with other plant extracts containing phytomelatonin in universally effective clinical applications and an adjuvant therapy specially during Polycystic Ovarian Syndrome ...
Highlights
PUBLIC INTEREST STATEMENTPolycystic ovarian syndrome (PCOS)—a most common endocrine disorder noted among women
Since decades, the pineal gland was considered as calcified vestige and as Descartes “Seat of the soul.” During the end of 1950, a very rapid progress has been made in uncovering functions of the pineal gland as so for its hormone melatonin
A Japanese study found that melatonin levels varied significantly between night- and day-shift workers, while luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels did not, suggesting that the menstrual irregularity associated with shift work could be explained by melatonin fluctuations (Miyauchi, Nanjo, & Otsuka, 1992)
Summary
Polycystic ovarian syndrome (PCOS)—a most common endocrine disorder noted among women. A small lipophilic indoleamine, and reproductive hormones influencing sex steroid production at different stages of ovarian follicular maturation may be interrelated. It is a strong antioxidant and free radical scavenging molecule which may protect follicles from oxidative stress damages and rescue them from atresia, leading to complete follicular maturation and ovulation.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
