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Highlights
Armour & Patton write a helpful review on the use of Melatonin in children (Psychiatric Bulletin, June 2004, 28, 222-224)
It is important to consider that blind people have free-running circadian rhythms that are not amenable to the most powerful of resetting cues - light
The use of melatonin to trigger the new 24-hour period is very powerful in this population (Sack et al, 2000)
Summary
Armour & Patton write a helpful review on the use of Melatonin in children (Psychiatric Bulletin, June 2004, 28, 222-224). Several studies they mentioned were with blind subjects. Too low a dose and no effect, too high and the chronobiologic effects are lost and the direct somnolent action is experienced. It would be a shame if a potentially useful treatment for circadian rhythm disorders, including sleep disturbances and seasonal affective disorders, were discarded prematurely due to a perceived lack of efficacy
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