Abstract
BackgroundSevere acute pancreatitis is associated with high morbidity and mortality. Melatonin is known as the activator of antioxidant enzymes. The main purpose of this study was to evaluate the clinical effect of melatonin treatment in a pig model with induced acute pancreatitis.MethodsIn this study, acute pancreatitis was induced in 38 German domestic pigs (German Hybrid). After induction of acute pancreatitis, 18 animals were treated with melatonin. Intraoperative clinical data, postoperative blood parameters, fitness, and Porcine Well-being (PWB) score, and post-mortal histopathological data were analyzed in both study groups.ResultsThe matching procedure created two groups (melatonin group and control group) which were very similar. The fitness and PWB score were postoperative significantly enhanced in the melatonin group as compared to the control group (p = 0.005 and p = 0.003). Additionally, histological analysis revealed that acinar necrosis, fat tissue necrosis, and edema were significantly reduced in the melatonin group as compared to the non-melatonin group (p = 0.025, p = 0.003, and p = 0.028).ConclusionsPigs, which were treated with melatonin, were characterized by higher fitness and PWB scores than those of the control group. Moreover, melatonin treatment reduces the acinar necrosis, fat tissue necrosis, and edema of pancreatic tissue. Thus, melatonin might be a useful therapeutic option in severe acute pancreatitis.
Highlights
Acute pancreatitis is an inflammatory and potentially fatal disease [1]
It can be speculated that melatonin might be a useful therapeutic option in the treatment of severe acute pancreatitis
Induction of anesthesia and monitoring The animals were randomized in two groups: group 1, which were treated with melatonin after induction of acute necrotizing pancreatitis, and group 2
Summary
The initial management of acute pancreatitis is supportive and includes optimization of electrolyte and fluid balance, providing adequate caloric support and preventing complications [2]. Local complications such as pancreatic necrosis, pancreatic pseudocysts, pancreatic duct injury, and peripancreatic vascular complications are treated by a combination of endoscopic, radiologic, and surgical techniques [2]. The main purpose of this study was to further evaluate the clinical effect of melatonin treatment in pigs after induction of acute pancreatitis. The main purpose of this study was to evaluate the clinical effect of melatonin treatment in a pig model with induced acute pancreatitis
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