Abstract
To compare 24-hour melatonin level and timing in postpartum and nonpregnant nulliparous women. Melatonin release provides information regarding circadian rhythm timing, which influences health. 2-group comparison of data derived from intensive within-subject data collection. Participants' typical daily environment. 38 postpartum and 20 nonpregnant nulliparous women. Mothers' infants were 4 to 10 weeks of postnatal age. Urinary 6-sulfatoxymelatonin assayed from each voiding and corrected for volume using creatinine. Postpartum women had significantly higher baseline, lower maximum, lower percent rise, and differing pattern of 6-sulfatoxymelatonin than nonpregnant nulliparous women. Differences in melatonin suggest possible circadian rhythm disruption in the postnatal period.
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