Abstract
The effect of melatonin on luteinizing-hormone releasing-hormone stimulation of cyclic AMP accumulation and luteinizing hormone (LH) release from neonatal rat hemipituitaries was studied in vitro. Melatonin inhibited LH-release from pituitaries of animals kept previously on long but not on short photoperiods; cyclic AMP accumulation was, however, inhibited on both photoperiods. There were no daily changes in the melatonin effect. Inhibition of LH-release was strongly potentiated after 6 h preincubation with melatonin as compared with 20 min preincubation; cyclic AMP was not significantly affected by the length of preincubation.
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