Year-end Sale % OFF 
Abstract
Melatonin plays an essential role in the regulation of bone growth. The actions that melatonin exerts on odontoblasts may be similar to its action on osteoblasts. This research aimed to evaluate the pulp response to melatonin used for direct pulp capping to evaluate the antioxidant effect of melatonin administered orally and its influence on dental pulp. Direct pulp capping was performed on the upper molars of Sprague Dawley rats using melatonin or Mineral Trioxide Aggregate (MTA). The study groups were: MTA; Melatonin; MTA + Melatonin administered orally; and Melatonin + Melatonin administered orally. In the latter two groups, the animals drank water dosed with melatonin ad libitum (10 mg/100 mL). After 30 days, the animals were sacrificed, and 5 ml of blood, the kidneys, and the liver were extracted in order to evaluate oxidative stress using thiobarbituric acid reactive substances testing (TBARS). Fragments of the maxilla containing the study molars were prepared for histological evaluation. The degree of pulp inflammation and pulp necrosis, the presence of reparative dentin and dentin bridging the pulp chamber, the presence and regularity of the odontoblastic layer, and the presence of pulp fibrosis were evaluated. No significant differences were found between the four study groups for any of the studied histological variables. The oral administration of melatonin did not modify the local effects of MTA or melatonin on dental pulp, or reduce basal-level oxidative stress. The effect of melatonin on pulp is similar to that of MTA and may be used as an agent for direct pulp capping.
Highlights
Mineral Trioxide Aggregate (MTA) is commonly used in vital-pulp therapy, which has had histological, radiological, and clinical success
Histopathologic analysis revealed that all groups showed a dentinal reparative bridge by day 30 postprocedure (Figure 1), with viable pulp and a regular odontoblastic layer without signs of necrosis
No statistically significant differences were observed concerning degrees of inflammation between the four groups (p = 0.108), nor were significant differences found in the degree of necrosis between the treatment groups (p = 0.108)
Summary
Mineral Trioxide Aggregate (MTA) is commonly used in vital-pulp therapy, which has had histological, radiological, and clinical success. Vital-pulp therapy includes procedures such as direct pulp capping, indirect pulp capping, and partial or full pulpotomy [1,2,3,4]. Is commonly used for direct pulp capping and with sufficient biological responses; the main. Res. Public Health 2020, 17, 1043; doi:10.3390/ijerph17031043 www.mdpi.com/journal/ijerph
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Environmental Research and Public Health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
