Abstract
Researchers from University College London, Hopital Robert Debre, and Universite Paris Diderot, Paris assessed the neuroprotective effects of melatonin combined with therapeutic hypothermia after transient hypoxia-ischemia in a piglet model of perinatal asphyxia.
Highlights
Childhood obesity is independently associated with an increased risk of pediatric-onset multiple sclerosis (MS)/clinically isolated syndrome (CIS) in girls but not in boys
The authors speculate that the rapid rise and high estrogenic exposure of obese, peripubescent girls coupled with inflammatory mediators released by adipose tissue accelerate MS/CIS onset in adolescence
Researchers from University College London, Hopital Robert Debre, and Universite Paris Diderot, Paris assessed the neuroprotective effects of melatonin combined with therapeutic hypothermia after transient hypoxia-ischemia in a piglet model of perinatal asphyxia
Summary
Childhood obesity is independently associated with an increased risk of pediatric-onset MS/CIS in girls but not in boys. The authors speculate that the rapid rise and high estrogenic exposure of obese, peripubescent girls coupled with inflammatory mediators released by adipose tissue accelerate MS/CIS onset in adolescence. Pregnancy in females and tobacco smoke among males (Palacios N, et al Ann Epidemiol 2011 Jul;21(7):536-42), additional potential risk factors for MS, were not addressed in this study. The need to further address the progress of the childhood obesity epidemic is stressed, especially in girls
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