Abstract
We have compared the peroxyl radical scavenger ability of melatonin with that of vitamin E, vitamin C and reduced glutathione (GSH). In the assay system, β-phycoerythrin (β-PE) was used as fluorescent indicator protein, 2-2′-azo-bis(2-amidinopropane)dihydrochloride as a peroxyl radical generator and the water soluble vitamin E analogue, Trolox, as reference standard. Results are expressed as oxygen radical absorbing capacity (ORAC perox) units, where 1 ORAC unit equals the net protection produced by 1 μM Trolox. A linear correlation of ORAC values with concentration (0.5–4 μM) of all the substances tested has been observed. However, on molar basis, the relative ORAC perox of Trolox, vitamin C, GSH and melatonin was 1 : 1.12 : 0.68 : 2.04, respectively. Thus, melatonin, which is a lipid-soluble compound, was twice more active than vitamin E, believed to be the most effective lipophilic antioxidant.
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